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The Centers for Disease Control and Prevention's (CDC) Immunization Safety Office (ISO) is responsible for studying vaccine risks once vaccines are administered to the public.During the COVID-19 pandemic, ISO played a central role in vaccine safety evaluation. At the request of the CDC, the National Academies convened an expert committee to assess the ISO's statistical and epidemiological methods in vaccine risk monitoring and evaluation, including processes designed to detect, evaluate, and report potential problems associated with COVID vaccines. The committee also evaluated CDC's external communication strategies and provided recommendations to sustain and enhance ISO's vaccine risk monitoring and communication systems. The resulting report presents the committee's conclusions and recommendations.