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On December 3, 2018, the National Academies of Sciences, Engineering, and Medicine convened a workshop, hosted by New York University (NYU) Langone Health in New York City, to explore how evolving concepts of value in health care and business investments are leading to a shift in resources toward investments in health and well-being for all. Workshop participants explored what industry leaders are doing to make progress and avoid pitfalls, tools and platforms that are useful to these efforts, and lessons and insights that stakeholders can use to help reinforce the shift toward healthier investments. This publication summarizes the presentations and discussions from the workshop.