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Since its founding, the Center for Medicare & Medicaid Innovation(CMMI) has tested more than 50 alternative payment models reaching morethan 28 million patients across 528,000 health care providers andplans, yielding invaluable insights on the implementation of models toachieve better care, better health, and lower costs. On the other hand,many basic lessons learned are lessons unapplied. U.S. population healthoutcomes lag behind its highly economically developed peers and ourhealth system is still firmly entrenched in the fee-for-service paymentsystem that rewards service volume. This Special Publication suggests six key priority actions for CMMIcentered on signaling, mapping, measuring, modeling, partnering, anddemonstrating. These priority actions, coupled with implementationconsiderations that focus on meaningful and continuous engagement,intersectionality and diversity, and expanding CMMI activities andimpact, are intended to assist in aligning, supporting, and informingthe implementation of CMMIs Strategic Refresh.